What is Lissencephaly?Lissencephaly, which literally means "smooth brain," is a rare, gene-linked brain malformation characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). Lissencephaly may be associated with other diseases including isolated lissencephaly sequence, Miller-Dieker syndrome, and Walker-Warburg syndrome. In Lucy’s case, she also suffered from Miller-Dieker syndrome, which is disorder caused by the deletion of part of the small arm of 17th pair of chromosomes.
There is no cure for lissencephaly, but children can show progress in their development over time. Supportive care may be needed to help with comfort, feeding, and nursing needs. Seizures may be particularly problematic as well. The prognosis for children with lissencephaly depends on the degree of brain malformation. Many will pass before the age of 10 years. Some will survive, but show no significant development -- usually not beyond a 3- to 5-month-old level. |
Learn MoreFor more information on Lissencephaly and Miller-Dieker Syndrome, please visit the following links:
Lissencephaly Information Miller Dieker Syndrome Information |
